Anti-KDM4A Polyclonal Antibody (CABT-L2204) Knockout Validated

Rabbit Anti-Human KDM4A (Tyr141~Lys310) Polyclonal Antibody for WB

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human, Mouse
Immunogen
Recombinant fragment corresponding to human KDM4A (Tyr141~Lys310)
Conjugate
Unconjugated

Applications


Application Notes
Recommended dilution: WB: 0.2-2 ug/ml; 1:250-2500
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Data Examples


Knockout Varification: Lane 1: Wild-type MCF7 cell lysate. Lane 2: KDM4A knockout MCF7 cell lysate. Predicted MW: 120, 54kd, Observed MW: 50kd
Western Blot. Sample. Human Hela cell lysate.
Western Blot. Sample. Human MCF7 cell lysate.
Western Blot. Sample. Mouse Cerebrum lysate.

Target


Alternative Names
JMJD2; JMJD2A; JHDM3A; JmjC domain-containing histone demethylation protein 3A; Jumonji domain-containing protein 2A
Entrez Gene ID
UniProt ID

Product Background


Pathway
Chromatin modifying enzymes; Chromatin organization; HDMs demethylate histones;

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Hillringhaus, L; Yue, WW; et al. Structural and Evolutionary Basis for the Dual Substrate Selectivity of Human KDM4 Histone Demethylase Family. JOURNAL OF BIOLOGICAL CHEMISTRY 286:41616-41625(2011).
Tsurumi, A; Dutta, P; et al. Drosophila Kdm4 demethylases in histone H3 lysine 9 demethylation and ecdysteroid signaling. SCIENTIFIC REPORTS 3:-(2013).

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