Anti-Human β-lactoglobulin chimeric monoclonal antibody, clone 25I2

Name: Anti-Human β-lactoglobulin chimeric monoclonal antibody, clone 25I2
SKU: CABT-L2429
Rating: 5 (1 reviews)

Anti-Human β-lactoglobulin chimeric IgA consists of the human constant region of the heavy chain, mouse variable region of the heavy chain and mouse light chain. The human constant region of the heavy chain can be directly recognized by the anti-human conjugate, which is used in numerous in vitro diagnostic assays.

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COA

SDS

Datasheet

Summary

Specifications

Antibody Isotype

IgA

Clone

25I2

Conjugate

Unconjugated

Applications

Application Notes

Concentrations for use as standard, calibrator and/or positive control reagent in immunodiagnostic assays have to be individually determined by user.

Target

Alternative Names

β-Lactoglobulin; βLg

Citations

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Increased gut permeability and bacterial translocation are associated with fibromyalgia and myalgic encephalomyelitis/chronic fatigue syndrome: implications for disease-related biomarker discovery

Franz Martín, Manuel Blanco-Suárez, Paola Zambrano, Oscar Cáceres, Miriam Almirall, José Alegre-Martín, Beatriz Lobo, Ana Maria González-Castro , Javier Santos, Joan Carles Domingo, Joanna Jurek, Jesús Castro-Marrero

Frontiers in Immunology2023 SepPubMed ID: 37744357Read Article

Applications: IA
Reactive species: Unspecified reactive species
"Abstract: Background: There is growing evidence of the significance of gastrointestinal complaints in the impairment of the intestinal mucosal barrier function and inflammation in fibromyalgia (FM) and in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). However, data on intestinal permeability and gut barrier dysfunction in FM and ME/CFS are still limited with conflicting results. This study aimed to assess circulating biomarkers potentially related to intestinal barrier dysfunction and bacterial translocation and their association with self-reported symptoms in these conditions. Methods: A pilot multicenter, cross-sectional cohort study with consecutive enrolment of 22 patients with FM, 30 with ME/CFS and 26 matched healthy controls. Plasma levels of anti-beta-lactoglobulin antibodies (IgG anti-β-LGB), zonulin-1 (ZO-1), lipopolysaccharides (LPS), soluble CD14 (sCD14) and interleukin-1-beta (IL-1β) were assayed using ELISA. Demographic and clinical characteristics of the participants were recorded using validated self-reported outcome measures. The diagnostic accuracy of each biomarker was assessed using the receiver operating characteristic (ROC) curve analysis."
Article snippet: The results were given as antibody levels per ng/ml on a standard curve with anti-human beta-LGB chimera monoclonal antibody (clone 25I2;CABT-L2429; Creative Diagnostics, NY, USA) considering the dilution of each sample.