Anti-FBXW7 monoclonal antibody (CABT-30626MH)

Mouse anti-Human FBXW7 monoclonal antibody for ICC/IF, IHC-P, IP, WB Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
GCPY 4b0/2
Species Reactivity
Mouse, Human
Immunogen
Synthetic peptide (Human)
Conjugate
Unconjugated

Applications


Application Notes
WB: 1μg/ml; ICC/IF: 1/100; Flow Cyt: 1μg/106 cells
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
FBXW7; F-box and WD repeat domain containing 7; F box and WD 40 domain protein 7 (archipelago homolog, Drosophila); F-box/WD repeat-containing protein 7; AGO; archipelago homolog (Drosophila)
Entrez Gene ID
UniProt ID

Product Background


Gene summary
FBXW7 (F-Box And WD Repeat Domain Containing 7) is a Protein Coding gene. Diseases associated with FBXW7 include pediatric ependymoma and colon adenoma. Among its related pathways are Signaling by GPCR and Transport to the Golgi and subsequent modification. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and ubiquitin protein ligase binding. An important paralog of this gene is TRAF7. This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene.
Antigen Description
ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (PubMed:14739463). F-box/WD repeat-containing protein 7 is a protein that in humans is encoded by the FBXW7 gene. This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian, breast and colorectal cancer cell lines, implicating the genes potential role in the pathogenesis of human cancers. Three transcript variants encoding three different isoforms have been found for this gene. The function about FBXW7 antigen include protein binding; sequence-specific DNA binding transcription factor activity.
Pathway
Adaptive Immune System, organism-specific biosystem; Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem; Association of TriC/CCT with target proteins during biosynthesis, organism-specific biosystem; Chaperonin-mediated protein folding, organism-specific biosystem; Class I MHC mediated antigen processing & presentation, organism-specific biosystem; Delta-Notch Signaling Pathway, organism-specific biosystem; Immune System, organism-specific biosystem.

Citations


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References


Tzoneva, G; Ferrando, AA; et al. Recent Advances on NOTCH Signaling in T-ALL. NOTCH REGULATION OF THE IMMUNE SYSTEM 360:163-182(2012).
Guinney, J; Ferte, C; et al. Modeling RAS Phenotype in Colorectal Cancer Uncovers Novel Molecular Traits of RAS Dependency and Improves Prediction of Response to Targeted Agents in Patients. CLINICAL CANCER RESEARCH 20:265-272(2014).

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