Anti-FADD Polyclonal Antibody (CABT-L2021) Knockout Validated

Rabbit Anti-Human FADD (Leu7~Glu178) Polyclonal Antibody for WB

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
Recombinant fragment corresponding to human FADD (Leu7~Glu178)
Conjugate
Unconjugated

Applications


Application Notes
Recommended dilution: WB: 0.5-2 ug/ml
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Data Examples


Knockout Varification: Lane 1: Wild-type RaW264. 7 cell lysate. Lane 2: FADD knockout RaW264. 7 cell lysate. Predicted MW: 23kDa, Observed MW: 27kDa
Figure. Western Blot. Sample. Human Serum.

Target


Alternative Names
GIG3; MORT1; FADD Death Effector Domain; Fas-Associated Protein With Death Domain; Mediator Of Receptor-Induced Toxicity; Growth-Inhibiting Gene 3
Entrez Gene ID
UniProt ID

Product Background


Pathway
Activated TLR4 signalling; Alzheimers disease; Alzheimers Disease; Apoptosis; Apoptosis Modulation and Signaling; Apoptosis Modulation by HSP70; Caspase-8 activation by cleavage; Ceramide signaling pathway;

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Gniadecki, R; et al. Depletion of membrane cholesterol causes ligand-independent activation of Fas and apoptosis. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 320:165-169(2004).
Shao, RG; Cao, CX; et al. Activation of the Fas pathway independently of Fas ligand during apoptosis induced by camptothecin in p53 mutant human colon carcinoma cells. ONCOGENE 20:1852-1859(2001).

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