Anti-EBV Capsid Antigen P18 chimeric monoclonal antibody, clone B23G20D9

Name: Anti-EBV Capsid Antigen P18 chimeric monoclonal antibody, clone B23G20D9
SKU: CABT-L2404
Rating: 5 (1 reviews)

Anti-EBV Capsid Antigen P18 chimeric IgM consists of the human constant region of the heavy chain, mouse variable region of the heavy chain and mouse light chain. The human constant region of the heavy chain can be directly recognized by the anti-human conjugate, which is used in numerous in vitro diagnostic assays.

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COA

SDS

Datasheet

Summary

Specifications

Antibody Isotype

IgM

Clone

B23G20D9

Species Reactivity

Virus

Conjugate

Unconjugated

Applications

Application Notes

Concentrations for use as standard, calibrator and/or positive control reagent in immunodiagnostic assays have to be individually determined by user.

Target

Alternative Names

Epstein Barr Virus; EBV; Epstein–Barr virus; human herpesvirus 4; HHV-4; Human herpesvirus 4; EB virus

Citations

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Documents

pdf COA

pdf SDS

pdf Datasheet

QA & Reviews

Customer Reviews

References

Glutathione Peroxidase (GPx) and Superoxide Dismutase (SOD) in Oropharyngeal Cancer Associated with EBV and HPV Coinfection

VIRUSES-BASEL

Authors: Strycharz-Dudziak, Malgorzata; Foltyn, Sylwia; Dworzanski, Jakub; Kielczykowska, Malgorzata; Malm, Maria; Drop, Bartlomiej; Polz-Dacewicz, Malgorzata

Abstract

Recent reports have pointed to the link between persistent inflammation, oxidative stress, and carcinogenesis; however most of the studies concerning the role of viruses in head and neck cancer (HNC) are focused mainly on one type of virus. Our present study aimed to study the relationship between Epstein-Barr virus/human papilloma virus (EBV/HPV) coinfection and glutathione peroxidase (GPx) and superoxide dismutase (SOD) level in oropharyngeal cancer. Fresh-frozen tumor tissue samples were collected from 128 patients with oropharyngeal cancer infected with EBV or HPV or with EBV/HPV coinfection. After DNA extraction, EBV and HPV DNA was detected using a polymerase chain reaction (PCR) assay. GPx and SOD activity was determined in homogenates of cancer tissue using diagnostic kits produced by Randox Laboratories. Both GPx and SOD activity was statistically lower in patients with EBV/HPV coinfection than in a single EBV or HPV infection. Analysis of GPx and SOD activity in relation to histological grading and tumor, node (TN) classification revealed that in poorly-differentiated tumors, the level of antioxidant enzymes was lower compared with well-differentiated lesions and in cases with greater tumor dimensions and lymph-node involvement, both GPx and SOD activity was decreased. Further studies are necessary to clarify the influence of interplay between EBV, HPV, and oxidative stress on malignant transformation of upper aerodigestive tract epithelial cells.

Lymph node involvement by enteropathy-like indolent NK-cell proliferation

VIRCHOWS ARCHIV

Authors: Dargent, Jean-Louis; Tinton, Nicolas; Trimech, Mounir; de Leval, Laurence

Abstract

Natural killer (NK)-cell enteropathy (NKCE) and lymphomatoid gastropathy (LG) are closely related lymphoproliferative disorders (LPDs) composed of mature and Epstein-Barr virus (EBV)-negative NK-cells. Although these uncommon and indolent lymphoid proliferations mostly arise within the gastrointestinal (GI) tract as their designations implies, a few cases have been reported outside the GI tract. We hereby describe a unique case of lymph node infiltration by such EBV-negative NK-cell proliferation fortuitously found during routine examination of a gallbladder resected for biliary lithiasis. The histologic, phenotypic, and molecular features of this NK-cell proliferation, which were very similar if not identical to those previously reported in NKCE or LG, suggest that similar indolent EBV-negative NK-cell LPDs may also occasionally involve lymph nodes.