Anti-DKC Polyclonal Antibody (CABT-L2206) Knockout Validated

Rabbit Anti-Human DKC (Arg298~Leu465) Polyclonal Antibody for WB

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
Recombinant fragment corresponding to human DKC1 (Arg298~Leu465)
Conjugate
Unconjugated

Applications


Application Notes
Recommended dilution: WB: 0.5-2 ug/ml; 1:250-1000
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Data Examples


Knockout Varification: Lane 1: Wild-type HepG2 cell lysate. Lane 2: DKC knockout HepG2 cell lysate. Predicted MW: 58, 48kd, Observed MW: 58kd
Figure. Western Blot. Sample. Lane1: Human HepG2 Cells; Lane2: Human Jurkat Cells; Lane3: Human Hela Cells.

Target


Alternative Names
DKC1; NAP57; NOLA4; NAP57; Dyskeratosis Congenita 1; H/ACA Ribonucleoprotein Complex Subunit 4
UniProt ID

Product Background


Pathway
Cell Cycle; Chromosome Maintenance; Extension of Telomeres; H/ACA ribonucleoprotein complex; Regulation of Telomerase; Ribosome biogenesis in eukaryotes; Telomere Extension By Telomerase; Telomere Maintenance;

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Knight, SW; Heiss, NS; et al. X-linked dyskeratosis congenita is predominantly caused by missense mutations in the DKC1 gene. AMERICAN JOURNAL OF HUMAN GENETICS 65:50-58(1999).
Bellodi, C; McMahon, M; et al. H/ACA Small RNA Dysfunctions in Disease Reveal Key Roles for Noncoding RNA Modifications in Hematopoietic Stem Cell Differentiation. CELL REPORTS 3:1493-1502(2013).

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