Anti-CASP1 Polyclonal Antibody (CABT-L2043) Knockout Validated

Rabbit Anti-Human CASP1 (Asn120~Asp297) Polyclonal Antibody for WB

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human, Pig
Immunogen
Recombinant fragment corresponding to human CASP1 (Asn120~Asp297)
Conjugate
Unconjugated

Applications


Application Notes
Recommended dilution: WB: 0.5-2 ug/ml
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Data Examples


Knockout Varification: Lane 1: Wild-type Raji cell lysate. Lane 2: CASP1 knockout Raji cell lysate. Predicted MW: 10, 30, 35, 43, 45kDa, Observed MW: 42kDa
Figure. Western Blot. Sample. Lane1: Porcine Spleen Tissue ; Lane2: Porcine Lung Tissue; Lane3: Human Hela Cells; Lane4: Human Raji Cells.

Target


Alternative Names
ICE; IL1BC; IL1-BC; P45; Interleukin 1 Beta Converting Enzyme; Apoptosis-Related Cysteine Peptidase
Entrez Gene ID
UniProt ID

Product Background


Pathway
Amyotrophic lateral sclerosis (ALS); Apoptosis; Caspase cascade in apoptosis; Cellular roles of Anthrax toxin; Cytokine Signaling in Immune system; Cytosolic DNA-sensing pathway; Direct p53 effectors; IFN-gamma pathway;

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Wagner, L; Marschall, V; et al. Smac mimetic sensitizes glioblastoma cells to Temozolomide-induced apoptosis in a RIP1-and NF-kappa B-dependent manner. ONCOGENE 32:988-997(2013).
Chang, CH; Wang, Y; et al. Extensive crosslinking of CD22 by epratuzumab triggers BCR signaling and caspase-dependent apoptosis in human lymphoma cells. MABS 7:199-211(2015).

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