Zeta Globin ELISA Kit (DEIA2141)

Regulatory status: For research use only, not for use in diagnostic procedures.

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Size
96T
Sample
whole blood
Species Reactivity
Human
Intended Use
The product is a solid phase enzyme linked immunosorbent assay. This test provides rapid screening for the determination of elevated Zeta globin levels in whole blood to aid in the detection α-thalassemia-1 carrier resulting deletion.
Contents of Kit
1. Microwell strips
2. Sample Diluent
3. Washing concentrate
4. Enzyme conjugate
5. Negative Control
6. Positive Control
7. Solution A
8. Solution B
9. Stop Solution
Storage
Store all contents at 2-8°C. For more detailed information, please download the following document on our website.

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References


Anticorrosion film of benzimidazole on brass in ammonia

JOURNAL OF THE INDIAN CHEMICAL SOCIETY

Authors: Bag, SK; Chakraborty, SB; Chaudhuri, SR

Benzimidazole (Hbz) forms a highly stable insoluble film impeding dissolution of brass ill ammonia. It is a mixed inhibitor, inhibiting primarily by blocking the reaction centres. Rise of temperature favours corrosion, but to a much lesser extent in presence of inhibitors, because of chemisorption, leading to a net increase in inhibition efficiency. From ir and electronic spectral measurements, the anticorrosion film has been ascribed to formation of bis-benzimidazolato complexes of Cu-II and Zn-II.

HTLV-1 bZIP factor impedes the menin tumor suppressor and upregulates JunD-mediated transcription of the hTERT gene

CARCINOGENESIS

Authors: Borowiak, Malgorzata; Kuhlmann, Anne-Sophie; Girard, Sophie; Gazzolo, Louis; Mesnard, Jean-Michel; Jalinot, Pierre; Dodon, Madeleine Duc

Telomerase activity in cancer cells is dependent on the transcriptional regulation of the human telomerase reverse transcriptase (hTERT) gene, encoding the catalytic subunit of human telomerase. We have shown previously that HTLV-1 basic leucine zipper (HBZ), a viral regulatory protein encoded by the human retrovirus, human T-cell leukemia virus, type 1 (HTLV-1) cooperates with JunD to enhance hTERT transcription in adult T-cell leukemia (ATL) cells. Menin, the product of the tumor-suppressor MEN-1 gene, also interacts with JunD, represses its transcriptional activity and downregulates telomerase expression. The main objective of this study was to examine how menin and HBZ get involved in the regulation of hTERT transcription. In this study, we report that JunD and menin form a repressor complex of hTERT transcription in HBZ-negative cells. Conversely, in HBZ-positive cells, the formation of a JunD/HBZ/menin ternary complex and the recruitment of p300 histone acetyl transferase activity by HBZ lead to a decreased activity of the JunDmenin suppressor unit that correlates with the activation of hTERT transcription. Silencing HBZ or menin expression in ATL cells confirms that these proteins are differentially involved in telomerase regulation. These results propose that HBZ, by impeding the tumor-suppressor activity of menin, functions as a leukemogenic cofactor to upregulate gene transcription and promote JunD-mediated leukemogenesis.

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