Human ZBED2 blocking peptide (CDBP3224)

Synthetic Human ZBED2 blocking peptide for BL

Product Overview
Blocking peptide for anti-ZBED2 antibody
Target
ZBED2
Nature
Synthetic
Species Reactivity
Human
Tag/Conjugate
Unconjugated
Application Notes
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not suitable for human or animal consumption.
Procedure
None
Format
Liquid
Concentration
200 μg/ml
Size
50 μg
Buffer
PBS containing 0.02% sodium azide
Preservative
0.02% Sodium Azide
Storage
Store at -20℃, stable for one year.
UniProt ID
Antigen Description
ZBED2 (zinc finger, BED-type containing 2) is a protein-coding gene. Diseases associated with ZBED2 include gastric cancer. GO annotations related to this gene include DNA binding and metal ion binding. An important paralog of this gene is ZBED3.
Function
DNA binding; metal ion binding;
Synonyms
ZBED2; zinc finger, BED-type containing 2; zinc finger BED domain-containing protein 2; MGC10796; zinc finger, BED domain containing 2;

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References


Single-Cell Transcriptomics Reveals Spatial and Temporal Turnover of Keratinocyte Differentiation Regulators

FRONTIERS IN GENETICS

Authors: Finnegan, Alex; Cho, Raymond J.; Luu, Alan; Harirchian, Paymann; Lee, Jerry; Cheng, Jeffrey B.; Song, Jun S.

Keratinocyte differentiation requires intricately coordinated spatiotemporal expression changes that specify epidermis structure and function. This article utilizes single-cell RNA-seq data from 22,338 human foreskin keratinocytes to reconstruct the transcriptional regulation of skin development and homeostasis genes, organizing them by differentiation stage and also into transcription factor (TF)-associated modules. We identify groups of TFs characterized by coordinate expression changes during progression from the undifferentiated basal to the differentiated state and show that these TFs also have concordant differential predicted binding enrichment in the super-enhancers previously reported to turn over between the two states. The identified TFs form a core subset of the regulators controlling gene modules essential for basal and differentiated keratinocyte functions, supporting their nomination as master coordinators of keratinocyte differentiation. Experimental depletion of the TFs ZBED2 and ETV4, both predicted to promote the basal state, induces differentiation. Furthermore, our single-cell RNA expression analysis reveals preferential expression of antioxidant genes in the basal state, suggesting keratinocytes actively suppress reactive oxygen species to maintain the undifferentiated state. Overall, our work demonstrates diverse computational methods to advance our understanding of dynamic gene regulation in development.

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