Vancomycin [BSA] (DAG3035)

Product Overview
Vancomycin, BSA-Conjugated
Target
Vancomycin
Nature
Synthetic
Tag/Conjugate
BSA
Application Notes
Matched pair antibody available for Vancomycin [BSA] : Vancomycin antibody (Catalog # HMABPY054)
Procedure
None
Format
Liquid
Size
1 mg
Buffer
Supplied in 0.015 M phosphate, 0.15 M NaCl, pH 7.2
Preservative
0.1% Sodium Azide
Storage
2-8°C short term, -20°C long term
Warnings
PLEASE note that this product is intended for research use only; not for diagnostic or clinical use.
Introduction
Until recently, Vancomycin was one of the most powerful antibiotics that no bacterial cell had resistance to. Vancomycin is a very successful glycopeptide antibiotic, attacking the D alanyl D alanine component of the cell wall. By binding to the D alanyl D alanine component, Vancomycin is able to interrupt the normal cell wall formation. However, recently cells have achieved resistance to vancomycin. The reason that the resistance is so effective is that these cells have modified the D alanyl D alanine components of the cell wall into D alanyl D lactate components. Although this may sound easy, the actual process involves a series of five or more genes.
Keywords
ARMAPE; MOUSE PAI-1; MOUSE PLASMINOGEN ACTIVATOR INHIBITOR-1; PAI-1; PAI-1, HUMAN; PAI-1, MOUSE; PAI-1, MUTANT, MOUSE; PAI-1, RAT; PLASMINOGEN ACTIVATOR INHIBITOR-1, HUMAN; PLASMINOGEN ACTIVATOR INHIBITOR-1, HUMAN, RECOMBINANT; PLASMINOGEN ACTIVATOR INHIB

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References


Surgeon practice patterns for pre-soaking ACL tendon grafts in vancomycin: a survey of the ACL study group

KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

Authors: Xiao, Michelle; Sherman, Seth L.; Safran, Marc R.; Abrams, Geoffrey D.

Purpose To survey members of The ACL study group to determine the current practice patterns surrounding the technique of pre-soaking ACL grafts in vancomycin. Methods A web-based questionnaire was distributed to members of the ACL Study Group. Questions included the use of vancomycin solution for graft soaking during ACL reconstruction, their protocol for soaking the graft, vancomycin concentration utilized, graft choices, and concerns with the technique. Results Sixty-six (57%) ACL surgeons completed the survey. Approximately one-third (37.9%) of respondents currently pre-soak their ACL grafts in vancomycin prior to implantation, with 60% of these surgeons being from Europe. Seventy-six percent have adopted this practice within the past 5 years. The majority of surgeons wrap the graft in a vancomycin-soaked gauze prior to implantation (56%), soak for a variable amount of time before implantation (56%), use a concentration of 5 mg/mL (68%), and soak hamstring grafts (92%). Concerns included the mechanical properties of the graft (35%), cost of vancomycin (23%), availability (12%), and antibiotic resistance (9%). Conclusion This survey demonstrates that 37.9% of ACL study group members currently utilize vancomycin to pre-soak ACL tendon grafts as a means to decrease post-operative infection risk, with the majority of surgeons having implemented this practice within the past 5 years. The biggest concern towards using vancomycin was the mechanical properties of the graft after soaking.

Perichondritis: inspect the lobule

INTERNATIONAL JOURNAL OF EMERGENCY MEDICINE

Authors: Bress, Eli; Cohn, Jason E.

Case presentation This is a brief report of a 57-year-old Caucasian female presented with a 4-day history of worsening left ear pain. Her symptoms began with left otalgia and otorrhea which progressed to helical erythema, prompting a visit to the emergency department. She was noted to have erythema of the left auricle and swelling of the left auditory meatus. Our otolaryngology service observed erythema of the auricle with sparing of the lobule. Diagnosis The diagnosis to be otitis externa with perichondritis was established, and we recommended otic ciprofloxacin-hydrocortisone, IV vancomycin, and ciprofloxacin. The patient had marked improvement and was discharged on an oral and otic fluoroquinolone. In this case, the diagnosis of perichondritis was made by a classic physical examination finding: erythema and edema with sparing of the fatty lobule. This key finding helps to distinguish perichondritis from otitis externa.

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