VprBP may act as a receptor for CUL4-DDB1 ubiquitin ligase complex. In case of HIV1 infection, this protein is recruited by HIV1 VPR protein which is believed to result in an arrest of the cell cyccle in the G2 phase.
Function
ATP binding; histone kinase activity (H2A-T120 specific); protein binding;
Synonyms
VPRBP; Vpr (HIV-1) binding protein; DCAF1; protein VPRBP; Vpr-binding protein; vpr-interacting protein; HIV-1 Vpr-binding protein; DDB1 and CUL4 associated factor 1; DDB1- and CUL4-associated factor 1; serine/threonine-protein kinase VPRBP;
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