Alternative Names
(+)-Tramadol; cis-Tramadol; 27203-92-5
Concentration
Batch dependent - please inquire should you have specific requirements
Storage
2-8°C short term, -20°C long term
Introduction
(R,R)-tramadol is a 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol in which both stereocentres have R-configuration; the (R,R)-enantiomer of the racemic opioid analgesic tramadol, it exhibits ten-fold higher analgesic potency than the (S,S)-enantiomer. It has a role as a delta-opioid receptor agonist, a kappa-opioid receptor agonist, a mu-opioid receptor agonist, an adrenergic uptake inhibitor, an antitussive, a capsaicin receptor antagonist, a muscarinic antagonist, a nicotinic antagonist, a NMDA receptor antagonist, an opioid analgesic, a serotonergic antagonist, a serotonin uptake inhibitor and a metabolite. It is a conjugate base of a (R,R)-tramadol(1+). It is an enantiomer of a (S,S)-tramadol.
Keywords
Tramadol; Conzip, Durela, Qdolo
Citations
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Lelievre, B; Bretaudeau, M; et al. IMMUNOCHROMATOGRAPHIC TESTS: FALSE-POSITIVE RESULTS FOR METHADONE AND PHENCYCLIDINE AFTER ACUTE POISONING WITH TRAMADOL AND DEXTROPROPOXYPHENE. ACTA CLINICA BELGICA 65:12-17(2010).
Zhang, LZ; Guo, Z; et al. Tramadol reduces myocardial infarct size and expression and activation of nuclear factor kappa B in acute myocardial infarction in rats. EUROPEAN JOURNAL OF ANAESTHESIOLOGY 26:1048-1055(2009).