Human Threonyl-tRNA Synthetase (PL-7) [His] (DAG4860)

Human Threonyl-tRNA Synthetase (PL-7) [His], recombinant protein from Baculovirus Datasheet

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Product Overview
Recombinant human Threonyl-tRNA Synthetase (PL-7), his-tagged
Nature
Recombinant
Tag/Conjugate
His
Purity
SDS-PAGE (purity > 90%); Western blot with i: Polymyositis sera; ii:monoclonal anti-hexa-His-tag antibody.
Concentration
0.3-0.8 μg/ml (depending on the type of ELISA plate and coating buffer). Suitable for labeling of functional groups.
Storage
2-8°C short term, -20°C long term
Antigen Description
Threonyl-tRNA synthetase is a member of the aminoacyl-tRNA synthetase family, key enzymes of protein biosynthesis which charge tRNA molecules with the respective amino acids. This 83 kDa protein is an autoantigen recognized by PL-7 antibodies which occur in a subset of patients with polymyositis and dermatomyositis. It could be shown that PL-7 antibodies (similar to Jo-1 antibodies) indicate an increased risk for lung involvement.
Keywords
threonyl-tRNA synthetase; 11572; Ensembl:ENSG00000113407; MGC9344; threonine--tRNA ligase, cytoplasmic; threonine tRNA ligase 1, cytoplasmic; threonyl-tRNA synthetase, cytoplasmic; 6.1.1.3; TARS; ThrRS

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