Yeast Thioredoxin 1 (DAG4448)

Yeast Thioredoxin 1, recombinant protein from E. coli Datasheet

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Product Overview
Yeast Thioredoxin 1
Nature
Recombinant
Tag/Conjugate
Unconjugated
Concentration
1.0 mg/ml
Buffer
20mM Tris, pH 7.5/10mM NaCl/1mM EDTA
Storage
2-8°C short term, -20°C long term
Introduction
Thioredoxins (Trx) are small, multi-functional proteins with oxidoreductase activity and are ubiquitous in essentially all living cells. Trx contains a redox-active disulfide/dithiol group within the conserved Cys-Gly-Pro-Cys active site. The two cysteine residues in the conserved active centers can be oxidized to form intramolecular disulfide bonds. Reduction of the active site disulfide in oxidized Trx is catalyzed by Trx reductase with NADPH as the electron donor. The reduced Trx is a hydrogen donor for ribonucleotide reductase, the essential enzyme for DNA synthesis, and a potent general protein disulfide reductase with numerous functions in growth and redox regulations. Specific protein disulfide targets for reduction by Trx include protein disulfide –isomerase (PDI) and a number of transcription factors such as p53, NFkB and AP-1 (T1–151). Trx is also capable of removing H2O2, particularly when it is coupled with either methionine sulfoxide reductase or several isoforms of peroxiredoxins.
Keywords
TXN; thioredoxin; TRX; ADF; Surface associated sulphydryl protein; TXN protein; ATL derived factor; ATL-derived factor; DKFZp686B1993; MGC61975; SASP; Surface-associated sulphydryl protein; THIO_HUMAN; Thioredoxin; TRDX;

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