Tetanus Toxin C-Fragment
> 95%, by SDS-CGE under reducing conditions
Lyophilized in phosphat buffer, pH 7.5
2-8°C short term, -20°C long term
Tetanus toxin is an extremely potent neurotoxin produced by the vegetative cell of Clostridium tetani in anaerobic conditions, causing tetanus. It has no known function for clostridia in the soil environment where they are normally encountered. It is also called spasmogenic toxin, tetanospasmin or abbreviated to TeTx or TeNT. The LD50 of this toxin has been measured to be approximately 1 ng/kg, making it second only to Botulinin toxin D as the deadliest toxin in the world. However, these tests are conducted solely on mice which may react differently to certain toxins than humans and other animals.
Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhi
Clostridium tetani toxoid; Tentoxylysin; Tetanus toxin; tetX; TETANUS TOXOID, CLOSTRIDIUM TETANI