Anti-TRIM28 monoclonal antibody (DMABT-H12788)

Mouse anti-Human TRIM28 monoclonal antibody for WB, IHC, IF, ELISA, RNAi Knockdown Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2b
Clone
5F7
Species Reactivity
Human, Mouse, Rat
Immunogen
TRIM28 (AAH04978, 379 a.a. ~ 524 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
TRIM28; tripartite motif containing 28; transcription intermediary factor 1-beta; KAP1; RNF96; TF1B
Entrez Gene ID
UniProt ID

Product Background


Gene summary
TRIM28 (Tripartite Motif Containing 28) is a Protein Coding gene. Diseases associated with TRIM28 include setx. Among its related pathways are Gene Expression and p53 pathway (Pathway Interaction Database). GO annotations related to this gene include poly(A) RNA binding and sequence-specific DNA binding. An important paralog of this gene is AIRE. The protein encoded by this gene mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region.
Pathway
C-MYB transcription factor network, organism-specific biosystem; E2F transcription factor network, organism-specific biosystem; Gene Expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem; p53 pathway, organism-specific biosystem.

Citations


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References


Kijanka, G; Hector, S; et al. Human IgG antibody profiles differentiate between symptomatic patients with and without colorectal cancer. GUT 59:69-78(2010).
Satoh, M; Chan, JYF; et al. Autoantibodies to transcription intermediary factor (TIF)1 beta associated with dermatomyositis. ARTHRITIS RESEARCH & THERAPY 14:-(2012).

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