This gene encodes a member of the serine protease family. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified as a gene overexpressed in pancreatic carcinoma. The encoded protein is membrane bound with a N-terminal anchor sequence and a glycosylated extracellular region containing the serine protease domain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Nguyen, TH; Weber, W; et al. Expression of TMPRSS4 in non-small cell lung cancer and its modulation by hypoxia. INTERNATIONAL JOURNAL OF ONCOLOGY 41:829-838(2012).
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