This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8. [provided by RefSeq, Jul 2008]
Function
protein binding; protein complex binding; syntaxin binding
Synonyms
TMED10; transmembrane emp24-like trafficking protein 10 (yeast); p23; TMP21; S31I125; Tmp-21-I; S31III125; P24(DELTA); transmembrane emp24 domain-containing protein 10; p24delta; p24delta1; p24 family protein delta-1; transmembrane protein Tmp21; 21 kDa transmembrane trafficking protein; 21 kDa transmembrane-trafficking protein
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