Human TLR6 blocking peptide (CDBP2994)

Synthetic Human TLR6 blocking peptide for BL

Product Overview
Blocking peptide for anti-TLR6 antibody
Target
TLR6
Nature
Synthetic
Species Reactivity
Human
Tag/Conjugate
Unconjugated
Application Notes
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not suitable for human or animal consumption.
Procedure
None
Format
Liquid
Concentration
200 μg/ml
Size
50 μg
Buffer
PBS containing 0.02% sodium azide
Preservative
0.02% Sodium Azide
Storage
Store at -20℃, stable for one year.
UniProt ID
Antigen Description
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain of the encoded protein may be associated with an increased of asthma is some populations.[provided by RefSeq, Jan 2011]
Function
diacyl lipopeptide binding; lipopeptide binding; protein heterodimerization activity; receptor activity; transmembrane signaling receptor activity;
Synonyms
TLR6; toll-like receptor 6; CD286;

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References


Farhat, K; Sauter, KS; et al. The response of HEK293 cells transfected with bovine TLR2 to established pathogen-associated molecular patterns and to bacteria causing mastitis in cattle. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY 125:326-336(2008).
He, J; You, XX; et al. Mycoplasma genitalium-Derived Lipid-Associated Membrane Proteins Activate NF-kappa B through Toll-Like Receptors 1, 2, and 6 and CD14 in a MyD88-Dependent Pathway. CLINICAL AND VACCINE IMMUNOLOGY 16:1750-1757(2009).

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