TARDBP blocking peptide

Nature

Synthetic

Tag/Conjugate

Unconjugated

Format

Liquid

Concentration

200 μg/mL

Preservative

None

Storage

-20°C

Entrez Gene ID

Antigen Description

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008]

Function

RNA binding; double-stranded DNA binding; identical protein binding; mRNA 3'-UTR binding; nucleotide binding; poly(A) RNA binding; protein binding; sequence-specific DNA binding transcription factor activity

Synonyms

TARDBP; TAR DNA binding protein; ALS10; TDP-43; TAR DNA-binding protein 43; TAR DNA-binding protein-43