The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Function
E-box binding; SMAD binding; bHLH transcription factor binding; enhancer binding; protein binding; protein heterodimerization activity; sequence-specific DNA binding transcription factor activity; transcription factor binding; contributes_to transcription regulatory region DNA binding
Synonyms
TCF12; transcription factor 12; HEB; CRS3; HTF4; bHLHb20; HsT17266; TCF-12; E-box-binding protein; DNA-binding protein HTF4; transcription factor HTF-4; helix-loop-helix transcription factor 4; class B basic helix-loop-helix protein 20
Citations
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