Tuberculosis IgM/IgG Rapid Test (DTS514)

Regulatory status: For research use only, not for use in diagnostic procedures.

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Size
50T
Sample
feces
Intended Use
The TB IgG/IgM Rapid Test is a sandwich lateral flow chromatographic immunoassay for the simultaneous detection and differentiation of IgM anti-Mycobacterium Tuberculosis (M.TB) and IgG anti- M.TB in human serum or plasma. It is intended to be used as a screening test and as an aid in the diagnosis of infection with M. TB. Any reactive specimen with the TB IgG/IgM Rapid Test must be confirmed with alternative testing method(s) and clinical findings.
Storage
1. Store the unused and unopened test kit at room temperature (2-30°C).
2. Each device may be used until the expiration date printed on the label if it remains sealed in the foil pouch containing desiccant.
3. Do not freeze the kit and or expose the kit t
Sensitivity
1. Clinical Performance for IgM Test: Relative Sensitivity: 93.3%
2. Clinical Performance For IgG Test: Relative Sensitivity: 94.6%

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References


Metformin enhances anti-mycobacterial responses by educating CD8+T-cell immunometabolic circuits

NATURE COMMUNICATIONS

Authors: Boehme, Julia; Martinez, Nuria; Li, Shamin; Lee, Andrea; Marzuki, Mardiana; Tizazu, Anteneh Mehari; Ackart, David; Frenkel, Jessica Haugen; Todd, Alexandra; Lachmandas, Ekta; Lum, Josephine; Shihui, Foo; Ng, Tze Pin; Lee, Bernett; Larbi, Anis; Netea, Mihai G.; Basaraba, Randall; van Crevel, Reinout; Newell, Evan; Kornfeld, Hardy; Singhal, Amit

Patients with type 2 diabetes (T2D) have a lower risk of Mycobacterium tuberculosis infection, progression from infection to tuberculosis (TB) disease, TB morality and TB recurrence, when being treated with metformin. However, a detailed mechanistic understanding of these protective effects is lacking. Here, we use mass cytometry to show that metformin treatment expands a population of memory-like antigen-inexperienced CD8(+)CXCR3(+) T cells in naive mice, and in healthy individuals and patients with T2D. Metformin-educated CD8(+) T cells have increased (i) mitochondrial mass, oxidative phosphorylation, and fatty acid oxidation; (ii) survival capacity; and (iii) anti-mycobacterial properties. CD8(+) T cells from Cxcr3(-/-) mice do not exhibit this metformin-mediated metabolic programming. In BCG-vaccinated mice and guinea pigs, metformin enhances immunogenicity and protective efficacy against M. tuberculosis challenge. Collectively, these results demonstrate an important function of CD8(+) T cells in metformin-derived host metabolic-fitness towards M. tuberculosis infection. Metformin is an anti-diabetic drug that has shown promise to reduce M. tuberculosis susceptibility. Here the authors show that this effect is a result of metformin-mediated activation of anti-mycobacterial memory-like antigen-inexperienced CD8(+)CXCR3(+) T cells, an effect that also boosts response to BCG vaccination.

Is moving from targeted culling to BCG-vaccination of badgers (Meles meles) associated with an unacceptable increased incidence of cattle herd tuberculosis in the Republic of Ireland? A practical non-inferiority wildlife intervention study in the Republic of Ireland (2011-2017)

PREVENTIVE VETERINARY MEDICINE

Authors: Martin, S. W.; O'Keeffe, J.; Byrne, A. W.; Rosen, L. E.; White, P. W.; McGrath, G.

Bovine tuberculosis (BTB) remains as a costly disease of cattle-herds in the Republic of Ireland (ROI). This persistence is partially attributable to the presence of M. bovis infection in a wildlife reservoir, the European badger (Meles meles). Thus, both area-wide and limited-area targeted-badger-culling have been part of the ROIBTB control/eradication program to help reduce the future incidence of a cattle-herd BTB breakdown (i.e. a "new herd-level occurrence of BTB"). However, neither badger-culling practice can be sustained as a major component in the ongoing BTB eradication program in the ROI. Vaccination of badgers with Bacille Calmette-Guerin (BCG) has been proposed as an alternative to badger culling. Thus, in 2011, a five-year non-inferiority study was implemented in seven counties in the ROI. This study was designed to compare and contrast the cattle-herd-BTB-incidence in areas where intramuscular badger vaccination would be implemented versus the cattle-herd-BTB-incidence in the remaining area of the same county where targeted-badger-culling was maintained as the standard treatment response to probable badger-sourced BTB breakdowns. Our outcome of interest was a new cattle-herd-BTB-episode (breakdown) with a total of > 2 standard skintest (SICTT) reactors detected during the episode. Treatments (badger vaccination or targeted badger culling) were cluster allocated based on where the majority of the herd owner's land was located. To assess the impact of the two treatments, we compared the incidence-risk, of our defined outcome, for cattle herds in the area under vaccination to the outcome incidence-risk for cattle herds in the remainder of the same county after 4 and 5 years of having implemented badger vaccination. A random-effects logit model with adjustment for clustering by treatment, and statistical control of herd type, herd-size and five-year prior-BTB-episode history was used for our analyses. Although not included in the logistic model, a relative badger density metric based on the annual number of badgers captured-per-sett-night of capturing effort was developed for each treatment area; this metric indicated that relative badger density was approximately 40 % higher in vaccination areas than in the targeted badger-culling areas during our study. Overall, our study results indicated that vaccination was not inferior to targeted badger-culling in four counties and badger vaccination was deemed to produce ambivalent results in one (County Cork North) of the seven study sites in the ROI. A post-study investigation, in County Galway, where vaccination was deemed inferior to target culling, revealed that widespread purchases of cattle from a nearby cattle mart, by herd owners in the vaccination-area, was associated with the increased herd and vaccination-area risk of BTB. No single "biasing hypothesis" was evident for the apparent vaccine inferiority in the second study site (County Monaghan) where vaccination was deemed inferior to targeted culling; hence no further investigations were conducted.

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