Thyroxine (T4) [HRP] (DAG3032)

Thyroxine (T4), HRP-Conjugated, synthetic

Product Overview
Thyroxine, HRP-Conjugated
Target
Thyroxine
Nature
Synthetic
Tag/Conjugate
HRP
Bio-activity
300 U /mg, pyrogallol
Procedure
None
Format
Liquid
Concentration
1.0 mg/mL
Size
1 mL
Buffer
1:1 glycerol / 0.015 M phosphate, 0.15 M NaCl, pH 7.2
Preservative
None
Storage
Store at -20°C.
Warnings
PLEASE note that this product is intended for research use only; not for diagnostic or clinical use.
Introduction
The thyroid hormones, triiodothyronine (T3) and its prohormone, thyroxine (T4), are tyrosine-based hormones produced by the thyroid gland that are primarily responsible for regulation of metabolism. Iodine is necessary for the production of T3 and T4. A deficiency of iodine leads to decreased production of T3 and T4, enlarges the thyroid tissue and will cause the disease known as simple goitre. The major form of thyroid hormone in the blood is thyroxine (T4), which has a longer half-life than T3. The ratio of T4 to T3 released into the blood is roughly 20 to 1. T4 is converted to the active T3 (three to four times more potent than T4) within cells by deiodinases (5'-iodinase). These are further processed by decarboxylation and deiodination to produce iodothyronamine (T1a) and thyronamine (T0a). All three isoforms of the deiodinases are selenium-containing enzymes, thus dietary selenium is essential for T3 production.
Keywords
Thyroxine

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References


Myxedema Coma: A Forgotten Medical Emergency With a Precipitous Onset

CUREUS

Authors: Acharya, Roshan; Cheng, Ce; Bourgeois, Michael; Masoud, John; McCray, Edwin

Myxedema coma is a rare life-threatening disorder characterized by severe hypothyroidism leading to multiorgan failure and even death. This case also reminds clinicians that the misnomer "coma" is misleading, and the patient can present with less severe symptoms. We present a case of a 72-year-old female with a history of primary hypothyroidism who presented to the emergency department with progressively worsening confusion for three days. Laboratory results revealed thyroid-stimulating hormone (TSH) 402.0 mu U/L and free thyroxine (T4) 0.22 ng/dL. The patient was compliant with the levothyroxine but she found to be malnourished on presentation. The patient was treated with intravenous levothyroxine and liothyronine. The patient's mental status improved to the baseline, and she was discharged to a skilled nursing facility. Myxedema coma is a rare but life-threatening disorder that providers should be familiar with, including management and treatment. To the best of our knowledge, this is the highest TSH level ever reported so far, and the first case of myxedema coma precipitated due to malnutrition.

THE SERUM TRIIODOTHYRONINE TO THYROXINE (T3/T4) RATIO IS ABLE TO PREDICT THERAPEUTIC OUTCOME IN ELDERLY IBD PATIENTS

DIGESTIVE AND LIVER DISEASE

Authors: Bertani, L.; Linsalata, G.; Svizzero, Baiano G.; Tapete, G.; Albano, E.; Mumolo, M. G.; Ceccarelli, L.; Maltinti, S.; Bellini, M.; Monzani, F.; Marchi, S.; Costa, F.

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