Neuroligins 3 and 4X interact with syntrophin-gamma 2, and the interactions are affected by autism-related mutations
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Authors: Yamakawa, Hidekuni; Oyama, Satoko; Mitsuhashi, Hiroaki; Sasagawa, Noboru; Uchino, Shigeo; Kohsaka, Shinichi; Ishiura, Shoichi
Abstract
Recently, neuroligins (NLs)3 and 4X have received much attention as autism-related genes. Here, we identified syntrophin-gamma 2 (SNTG2) as a de novo binding partner of NL3. SNTG2 also bound to NL4X and NL4Y. 1riterestingly, the binding was influenced by autism-related mutations, implying that the impaired interaction between NLs and SNTG2 contributes to the etiology of autism. (c) 2007 Elsevier Inc. All rights reserved.
2p25 deletion: involvement of SNTG2 in autism or behavioral problems, and parental imprinting.
CHROMOSOME RESEARCH
Authors: Plutino, Morgane; Karmous-Benailly, Houda; Giuliano, Fabienne; Massol, Christophe; Wagner, Kathy; Paquis-Flucklinger, Veronique; Dayem-Quere, Manal
Abstract