Sulfachloropyridazine [HRP]

Specificity

Each conjugate comprises antigen covalently bound to horseradish peroxide and is suitable as a tracer in immunoassay development.

Nature

Synthetic

Tag/Conjugate

HRP

Alternative Names

Sulfachloropyridazine; Sulfachlorpyridazine; 80-32-0; Sulphachlorpyridazine; Nefrosul; 4-amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide

Format

The conjugate is supplied as a concentrate. Dilute as required and use working strength conjugate immediately after dilution

Preservative

None

Storage

2 - 8°C for up to 3 months / -20°C for long term storage

Introduction

Sulfachloropyridazine is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfachloropyridazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. It is active against Gram positive bacteria, Gram negative bacteria and Chlamydia. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis. Sulfachloropyridazine is rapidly absorbed and rapidly excreted in the urine.