Human SmD3 [His], recombinant protein from Baculovirus
Recombinant human SmD3, his-tagged
SDS-PAGE (purity > 80%); Western blot with anti-Sm positive patient sera.
0.4-0.8 μg/ml (depending on the type of ELISA plate and coating buffer). Suitable for labeling of functional groups.
2-8°C short term, -20°C long term
The Sm antigen is part of the spliceosomal complex catalyzing the splicing of nuclear pre-mRNA. Each spliceosome snRNP consists of snRNAs (U1, U2, U4/U6, and U5) bound to a unique set of proteins as well as a shared set of seven different Sm proteins with molecular weights between 9 and 29.5 kDa (typically SmB/SmB', SmD1, SmD2, SmD3, SmE, SmF, SmG). Most frequently the SmB and SmD polypeptides are targets of the anti-Sm specific autoimmune response, of which SmD is regarded the most SLE-specific Sm antigen.
small nuclear ribonucleoprotein D3 polypeptide 18kDa; 11160; Ensembl:ENSG00000100028; small nuclear ribonucleoprotein Sm D3; snRNP core protein D3; small nuclear ribonucleoprotein polypeptide D3; SNRPD3; SMD3; Sm-D3