Human SmD1 [His] (DAG4839)

Human SmD1 [His], recombinant protein from Baculovirus Datasheet

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Product Overview
Recombinant human SmD1, his-tagged
DS-PAGE (purity > 80%); Western blot with anti-Sm positive patient sera.
0.4-0.8 μg/ml (depending on the type of ELISA plate and coating buffer). Suitable for labeling of functional groups.
2-8°C short term, -20°C long term
Antigen Description
The Sm antigen is part of the spliceosomal complex catalyzing the splicing of nuclear pre-mRNA. Each spliceosome snRNP consists of snRNAs (U1, U2, U4/U6, and U5) bound to a unique set of proteins as well as a shared set of seven different Sm proteins with molecular weights between 9 and 29.5 kDa (typically SmB/SmB', SmD1, SmD2, SmD3, SmE, SmF, SmG). Most frequently the SmB and SmD polypeptides are targets of the anti-Sm specific autoimmune response, of which SmD is regarded the most SLE-specific Sm antigen. A specific feature of the SmD1, SmD3, and SmB/B' proteins is the methylation by protein arginine methyltransferase 5 (PRMT5), a type II methyltransferase. Also, this symmetrical dimethylation of arginine residues by PRMT5 in SmD1 and SmD3 seems to be important for regulating the snRNP assembly
small nuclear ribonucleoprotein D1 polypeptide 16kDa; 11158; Ensembl:ENSG00000167088; small nuclear ribonucleoprotein Sm D1; Sm-D autoantigen; snRNP core protein D1; small nuclear ribonucleoprotein D1 polypeptide 16kDa pseudogene; SNRPD1; SMD1; SNRPD; Sm-


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