Human SEMA3A peptide (DAG-P1931)

Nature
Synthetic
Tag/Conjugate
Unconjugated
Cellular Localization
Plasma membrane and Secreted
Procedure
None
Purity
70 - 90% by HPLC.
Format
Liquid
Preservative
None
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.
UniProt ID
Antigen Description
This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimers disease. [provided by RefSeq, Jul 2008]
Function
chemorepellent activity; receptor activity; semaphorin receptor binding;
Synonyms
SEMA3A; sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A; HH16; SemD; COLL1; SEMA1; SEMAD; SEMAL; coll-1; Hsema-I; SEMAIII; Hsema-III; semaphorin-3A; collapsin 1; semaphorin D; semaphorin L; semaphorin III;

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References


Uchida, Y; Ohshima, T; et al. Semaphorin3A Signaling Mediated by Fyn-dependent Tyrosine Phosphorylation of Collapsin Response Mediator Protein 2 at Tyrosine 32. JOURNAL OF BIOLOGICAL CHEMISTRY 284:27393-27401(2009).
Giacobini, P; Parkash, J; et al. Brain Endothelial Cells Control Fertility through OvarianSteroid- Dependent Release of Semaphorin 3A. PLOS BIOLOGY 12:-(2014).

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