Human ABCC8 blocking peptide

Product Overview

Blocking/Immunizing peptide for anti-SUR1/ABCC8 antibody

Target

SUR1 / ABCC8

Nature

Synthetic

Tag/Conjugate

Unconjugated

Application Notes

For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.

Format

Lyophilized powder

Preservative

None

Storage

Shipped at ambient temperature, store at -20°C.

Entrez Gene ID

Antigen Description

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]

Function

ATP binding; ATPase activity, coupled to transmembrane movement of substances; ion channel binding; potassium ion transmembrane transporter activity; sulfonylurea receptor activity;

Synonyms

ABCC8; ATP-binding cassette, sub-family C (CFTR/MRP), member 8; HI; SUR; HHF1; MRP8; PHHI; SUR1; ABC36; HRINS; TNDM2; SUR1delta2; ATP-binding cassette sub-family C member 8; sulfonylurea receptor 1; sulfonylurea receptor (hyperinsulinemia); ATP-binding cassette transporter sub-family C member 8;