Product Overview
Blocking/Immunizing peptide for anti-SH2-B/SH2B1 antibody
Tag/Conjugate
Unconjugated
Application Notes
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.
Format
Lyophilized powder
Storage
Shipped at ambient temperature, store at -20°C.
Antigen Description
This gene encodes a member of the SH2-domain containing mediators family. The encoded protein mediates activation of various kinases and may function in cytokine and growth factor receptor signaling and cellular transformation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]
Function
signal transducer activity;
Synonyms
SH2B1; SH2B adaptor protein 1; SH2B adapter protein 1; FLJ30542; SH2 B homolog; SH2B; SH2-B signaling protein; SH2 domain-containing protein 1B; SH2 domain-containing putative adapter SH2-B; pro-rich, PH and SH2 domain-containing signaling mediator; PSM; KIAA1299; DKFZp547G1110;
Citations
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Qi, JP; Fang, XB; et al. Regulatory effects of nerve growth factor on SH2-B beta expression in the lung and primary afferent neurons of asthmatic mice. NEURAL REGENERATION RESEARCH 3:1132-1135(2008).
Zhang, MC; Riedel, H; et al. Insulin Receptor Kinase-Independent Signaling Via Tyrosine Phosphorylation of Phosphatase PHLPP1. JOURNAL OF CELLULAR BIOCHEMISTRY 107:65-75(2009).