Product Overview
Blocking/Immunizing peptide for anti-SFRP2 antibody
Tag/Conjugate
Unconjugated
Application Notes
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.
Format
Lyophilized powder
Storage
Shipped at ambient temperature, store at -20°C.
Antigen Description
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer. [provided by RefSeq, Jul 2008]
Function
PDZ domain binding; Wnt-activated receptor activity; Wnt-protein binding; endopeptidase activator activity; fibronectin binding; integrin binding; metalloenzyme activator activity; receptor agonist activity;
Synonyms
SFRP2; secreted frizzled-related protein 2; FRP 2; SARP1; SDF 5; SARP-1; sFRP-2; secreted apoptosis related protein 1; secreted apoptosis-related protein 1; FRP-2; SDF-5;
Citations
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Jones, SE; Jomary, C; et al. Altered expression of secreted frizzled-related protein-2 in retinitis pigmentosa retinas. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 41:1297-1301(2000).
Fontenot, E; Rossi, E; et al. A Novel Monoclonal Antibody to Secreted Frizzled-Related Protein 2 Inhibits Tumor Growth. MOLECULAR CANCER THERAPEUTICS 12:685-695(2013).