Product Overview
Blocking/Immunizing peptide for anti-SATB1 antibody
Tag/Conjugate
Unconjugated
Application Notes
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.
Format
Lyophilized powder
Storage
Shipped at ambient temperature, store at -20°C.
Antigen Description
This gene encodes a matrix protein which binds nuclear matrix and scaffold-associating DNAs through a unique nuclear architecture. The protein recruits chromatin-remodeling factors in order to regulate chromatin structure and gene expression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
Function
double-stranded DNA binding; protein binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity;
Synonyms
SATB1; SATB homeobox 1; special AT rich sequence binding protein 1 (binds to nuclear matrix/scaffold associating DNA); DNA-binding protein SATB1; special AT-rich sequence-binding protein 1; special AT-rich sequence binding protein 1 (binds to nuclear matrix/scaffold-associating DNA);
Citations
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Bortul, R; Zweyer, M; et al. Nuclear changes in necrotic HL-60 cells. JOURNAL OF CELLULAR BIOCHEMISTRY :19-31(2001).
Li, K; Cai, R; et al. SATB1 regulates SPARC expression in K562 cell line through binding to a specific sequence in the third intron. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 356:6-12(2007).