SARS-CoV-2 Antigen ELISA Kit

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a single-stranded RNA virus with a genome length of approximately 29.9kb. It consists of four proteins, with the spike protein being the primary antigen in approved vaccines. It can spread through various pathways such as respiratory droplets, contact, and aerosols. One of its characteristics is high infectivity, with an average of 2-3 people infected by each carrier. The infectious virus can persist in the host's respiratory secretions for up to 9 days after symptom onset. SARS-CoV-2 exhibits strong mutation capability, giving rise to variants like Alpha, Beta, Delta, Omicron, which differ in toxicity and immune evasion mechanisms, posing challenges for vaccine and treatment development.

Figure 1. The Structure and Replication Cycle of SARS-CoV-2 Virus (Source: Cevik M, et al., 2020)

SARS-CoV-2 mainly affects the respiratory tract, causing alveolar destruction, exudation, and pulmonary fibrosis.It can impact various organs, including the liver, brain, heart, and kidneys, triggering a severe but ineffectual immunological response. Aside from asymptomatic carriers, typical Coronavirus Disease 2019 (COVID-19) symptoms include fever, sore throat, cough, headache, exhaustion, muscle discomfort, diarrhea, conjunctivitis, and loss of smell and taste. In severe situations, it can lead to acute respiratory distress syndrome (ARDS), multiple organ failure, and unconsciousness. Since its discovery in 2019, SARS-CoV-2 has spread swiftly over the world, causing large-scale pandemics. As of 2024, it had killed 7 million people worldwide, with the elderly and those with comorbidities faring the worst.

Figure 2. Clinical Symptoms of COVID-19 (Source: Harrison AG, et al., 2020)

Currently, RT-PCR is the standard method to detect SARS-CoV-2 RNA in nasopharyngeal specimens for diagnosing COVID-19. Loop-mediated isothermal amplification (LAMP) serves as an alternative that overcomes some limitations of RT-PCR while maintaining sensitivity comparable to PCR. Additionally, virus detection technologies based on nanomaterials and clinical biosensors are under development. Comprehensive application of personal protective measures, vaccination, drug treatments, and public health measures is crucial in effectively controlling and preventing the spread and infection of SARS-CoV-2.

Figure 3: RT–PCR and LAMP assays for detection of SARS-CoV-2 infection(Source:, Kevadiya BD. et al., 2021)

COVID-19 Antigen ELISA Kit
Coronavirus Antigen ELISA Kit
SARS-CoV-2 Protein ELISA Kit
COVID-19 Protein Detection Kit