SARS-CoV-2 Antigen ELISA Kit (DEIA2020)

Regulatory status: For research use only, not for use in diagnostic procedures.

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Intended Use
This kit is intended for the quantitative detection of the recombinant SARS-COV-2 nucleoprotein antigen in human serum. It can recognize recombinant SARS-CoV Nucleoprotein / NP Protein, but no react with recombinant MERS-CoV Nucleoprotein / NP protein. The use of this kit for natural samples need be validated by the end user due to the complexity of natural targets and unpredictable interference.
The kit should be stored at 2 ~ 8 °C, protected from light, and valid for 6 months.
General Description
Coronaviruses are enveloped viruses with a positive-sense RNA genome and with a nucleocapsid of helical symmetry. Coronavirus nucleoproteins localize to the cytoplasm and the nucleolus, a subnuclear structure, in both virus-infected primary cells and in cells transfected with plasmids that express N protein. Coronavirus N protein is required for coronavirus RNA synthesis, and has RNA chaperone activity that may be involved in template switch. Nucleocapsid protein is a most abundant protein of coronavirus. During virion assembly, N protein binds to viral RNA and leads to formation of the helical nucleocapsid. Nucleocapsid protein is a highly immunogenic phosphoprotein also implicated in viral genome replication and in modulating cell signaling pathways. Because of the conservation of N protein sequence and its strong immunogenicity, the N protein of coronavirus is chosen as a diagnostic tool.


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Joe Biden must quickly restore science to government


Authors: [Anonymous]

The election of Joe Biden and Kamala Harris is a win for facts, research and empathy. The election of Biden and Kamala Harris is a win for facts, research and empathy. Each of these must be deployed to fight the pandemic, combat misinformation, mitigate climate change and rebuild the United States' global relationships.

Literature Analysis of the Efficacy of Arbidol in Virus Infectious Diseases


Authors: Liu, Ying; Shen, Chao; He, Zhiyao; Wei, Chunyan; Su, Na

Arbidol (ARB) is a broad-spectrum antiviral drug. However, its effects on virus infectious diseases remain unclear. We aimed to evaluate the efficacy of ARB in infectious virus diseases. We searched up to March 2020 in MEDLINE (Ovid SP), EMBASE (Ovid SP), Cochrane Central Register of Controlled Trials (CENTRAL), China National Knowledge Infrastructure (CNKI), for studies investigating ARB in virus infectious diseases. Descriptive analysis was made on the main results of the eligible articles that meet the inclusion criteria. Fifty-two studies were included finally, which involving influenza virus, respiratory syncytial virus (RSV), severe acute respiratory syndrome-coronaviruses (SARS-CoV), middle east respiratory syndrome-coronaviruses (MERS-CoV), hepatitis c virus (HCV), herpes simplex virus (HSV), severe acute respiratory syndromes-coronaviruses-2 (SARS-CoV-2), chikungunya virus (CHIKV), hantaan virus (HTNV), zika virus (ZIKV), coxsackievirus, lassa virus(LASV), Ebola virus (EBOV) and adenovirus (ADV). ARB is effective in the above viruses. Two studies showed that ARB was effective in SARS-CoV-2. In vivo and in vitro studies showed ARB had the capability of inhibiting SARS-CoV, MERS-CoV, HCV, HSV, ZIKV, CV, HTNV, ZIKV, CHIKV, LASV, EBOV, and ADV. Conclusion Clinical studies are still needed to confirm the efficacy of ARB in novel coronavirus pneumonia (COVID-19).

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