Human Ro/SS-A [His], recombinant protein from E. coli
Recombinant human Ro/SS-A (60 kDa), his-tagged
SDS-PAGE (purity > 90%); Western blot with i: SLE sera (secondary Sj. gren's syndrome); ii: monoclonal anti-hexa-His-tag antibody.
0.2-0.5 μg/ml (depending on the type of ELISA plate and coating buffer). Suitable for labeling of functional groups.
2-8°C short term, -20°C long term
Sj gren Syndrome, Subacute Cutaneous LE
The Ro/SS-A antigen is a ribonucleoprotein complex and consists of two major proteins of 52 and 60 kDa, complexed with one specific RNA chain (either hY1, hY2, hY3 or hY5, which all are transcripts of RNA polymerase III); the Ro/SS-A (60 kDa) protein is the RNA-binding protein in the complex. The cellular function of this complex is still unresolved, as is the question whether the antigen is primarily located in the cytoplasm or in the nucleus or even shuttles between the 2 compartments. Ro/SS-A antibodies occur with a prevalence of 60-90% in Sj gren syndrome patients, but also with a prevalence of 25-50% in SLE patients and higher prevalences in subacute cutaneous LE patients. Neonatal lupus syndrome (congenital heart block, photosensitivity, skin lesions) is also associated with the presence of Ro/SS-A autoantibodies in the maternal and neonatal sera, in particular when these autoantibodies are directed to the 52-kDa antigen.
TROVE domain family, member 2; 11313; Ensembl:ENSG00000116747; 60 kDa SS-A/Ro ribonucleoprotein; 60 kDa ribonucleoprotein Ro; sjoegren syndrome type A antigen; gastric cancer multi-drug resistance protein; Sjogren syndrome antigen A2 (60kD, ribonucleoprot