Human RIMS2 blocking peptide (CDBP2536)

Synthetic Human RIMS2 blocking peptide for BL

Product Overview
Blocking peptide for anti-Rim2 antibody
Species Reactivity
Application Notes
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not suitable for human or animal consumption.
200 μg/ml
50 μg
PBS containing 0.02% sodium azide
0.02% Sodium Azide
Store at -20℃, stable for one year.
UniProt ID
Antigen Description
RIMS2 (regulating synaptic membrane exocytosis 2) is a protein-coding gene. Diseases associated with RIMS2 include croup, and laryngotracheitis, and among its related super-pathways are Thyroid hormone synthesis. GO annotations related to this gene include Rab GTPase binding and metal ion binding. An important paralog of this gene is RIMS1.
Rab GTPase binding; metal ion binding; protein binding;
RIMS2; regulating synaptic membrane exocytosis 2; RAB3 interacting protein 3 , RAB3IP3; regulating synaptic membrane exocytosis protein 2; KIAA0751; OBOE; RIM2; RIM 2; nuclear protein; RAB3 interacting protein 3; rab-3-interacting protein 3; rab3-interacting molecule 2; rab-3-interacting molecule 2; non-small cell lung cancer RimL3a protein; non-small cell lung cancer RimL3c protein; RAB3IP3; DKFZp781A0653;


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Genome-wide association study identifies genes that may contribute to risk for developing heroin addiction


Authors: Nielsen, David A.; Ji, Fei; Yuferov, Vadim; Ho, Ann; He, Chunsheng; Ott, Jurg; Kreek, Mary Jeanne

Objectives We have used genome-wide association studies to identify variants that are associated with vulnerability to develop heroin addiction. Methods DNA from 325 methadone stabilized, former severe heroin addicts and 250 control individuals were pooled by ethnicity (Caucasian and African-American) and analyzed using the Affymetrix GeneChip Mapping 100K Set. Genome-wide association tests were conducted. Results The strongest association with vulnerability to develop heroin addiction, with experiment-wise significance (P = 0.035), was found in Caucasians with the variant rs10494334, a variant in an unannotated region of the genome (1q23.3). In African Americans, the variant most significantly associated with the heroin addiction vulnerability was rs950302, found in the cytosolic dual specificity phosphatase 27 gene DUSP27 (point-wise P = 0.0079). Furthermore, analysis of the top 500 variants with the most significant associations (point-wise P <= 0.0036) in Caucasians showed that three of these variants are clustered in the regulating synaptic membrane exocytosis protein 2 gene RIMS2. Of the top 500 variants in African-Americans (point-wise P <= 0.0238), three variants are in the cardiomyopathy associated 3 gene CMYA3. Conclusion This study identifies new genes and variants that may increase an individual's vulnerability to develop heroin addiction. Psychiatr Genet 20:207-214 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

Rare Copy Number Variations in a Chinese Cohort of Autism Spectrum Disorder


Authors: Fan, Yanjie; Du, Xiujuan; Liu, Xin; Wang, Lili; Li, Fei; Yu, Yongguo

Autism spectrum disorder (ASD) is heterogeneous in symptom and etiology. Rare copy number variations (CNVs) are important genetic factors contributing to ASD. Currently chromosomal microarray (CMA) detecting CNVs is recommended as a first-tier diagnostic assay, largely based on research in North America and Europe. The feature of rare CNVs has not been well characterized in ASD cohorts from non-European ancestry. In this study, high resolution CMA was utilized to investigate rare CNVs in a Chinese cohort of ASD (n = 401, including 177 mildly/moderately and 224 severely affected individuals), together with an ancestry-matched control cohort (n = 197). Diagnostic yield was about 4.2%, with 17 clinically significant CNVs identified in ASD individuals, of which 12 CNVs overlapped with recurrent autism risk loci or genes. Autosomal rare CNV burden analysis showed an over-representation of rare loss events in ASD cohort, whereas the rate of rare gain events correlated with the phenotypic severity. Further analysis showed rare losses disrupting genes highly intolerant of loss-of-function variants were enriched in the ASD cohort. Among these highly constrained genes disrupted by rare losses, RIMS2 is a promising candidate contributing to ASD risk. This pilot study evaluated clinical utility of CMA and the feature of rare CNVs in Chinese ASD, with candidate genes identified as potential risk factors.

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