Human Ribosomal Phosphoprotein P2 [His], recombinant protein from E. coli
Recombinant human Ribosomal Phosphoprotein P2, his-tagged
SDS-PAGE (purity > 80%); Western blot with i: SLE sera (Systemic Lupus Erythematosus); ii: monoclonal anti-hexa-His-tag antibody.
2-8°C short term, -20°C long term
The ribosomal phosphoproteins, also called P protein antigens, are associated with the large ribosomal subunit and therefore are antigenic targets with a cytoplasmic localization. Three P proteins have been described: P0 with a molecular weight of 35 kDa, P1 (19 kDa) and P2 (17 kDa). Autoantibodies against ribosomal P proteins are present in 10% of SLE patients. If anti-ribosomal P antibodies were to occur in the absence of other typical SLE associated autoantibodies, they may account for some patients with so-called ANA-negative lupus. It has been reported that lupus patients positive for anti-ribosomal P autoantibodies have a high frequency of CNS involvement, suggesting a marker use for these antibodies.
ribosomal protein, large, P2; 10377; Ensembl:ENSG00000177600; MGC71408; 60S acidic ribosomal protein P2; renal carcinoma antigen NY-REN-44; acidic ribosomal phosphoprotein P2; RPLP2; P2; LP2; RPP2; D11S2243E