Human Ribosomal Phosphoprotein P1 [His], recombinant protein from Baculovirus
Recombinant human Ribosomal Phosphoprotein P1, his-tagged
SDS-PAGE (purity > 80%); Western blot with i: SLE sera (Systemic Lupus Erythematosus); ii: monoclonal anti-hexa-His-tag antibody.
0.3–0.7 μg/ml (depending on the type of ELISA plate and coating buffer). Suitable for labeling of functional groups.
2-8°C short term, -20°C long term
The ribosomal phosphoproteins, also called P protein antigens, are associated with the large ribosomal subunit and therefore are antigenic targets with a cytoplasmic localization. Three P proteins have been described: P0 with a molecular weight of 35 kDa, P1 (19 kDa) and P2 (17 kDa). Autoantibodies against ribosomal P proteins are present in 10% of SLE patients. If anti-ribosomal P antibodies were to occur in the absence of other typical SLE associated autoantibodies, they may account for some patients with so-called ANA-negative lupus. It has been reported that lupus patients positive for anti-ribosomal P autoantibodies have a high frequency of CNS involvement, suggesting a marker use for these antibodies.
ribosomal protein, large, P1; 10372; Ensembl:ENSG00000137818; MGC5215, FLJ27448; 60S acidic ribosomal protein P1; acidic ribosomal phosphoprotein P1; RPLP1; P1; LP1; RPP1