Product Overview
Recombinant West Nile Virus Envelope Protein (N-terminus). Contains 6 histidines fusion sequence. Molecular weight approximately 42kDa. Reacts with human West Nile Virus positive serum. It was expressed in E. coli, and puried in vitro using conventional c
Purity
95% pure (SDS-PAGE)
Buffer
20mM Phosphate buffer, pH 7.5
Storage
2-8°C short term, -20°C long term
Introduction
West Nile virus (WNV) is a mosquito-borne zoonotic arbovirus belonging to the genus Flavivirus in the family Flaviviridae. This flavivirus is found in temperate and tropical regions of the world. It was first identified in the West Nile subregion in the East African nation of Uganda in 1937. Prior to the mid-1990s, WNV disease occurred only sporadically and was considered a minor risk for humans, until an outbreak in Algeria in 1994, with cases of WNV-caused encephalitis, and the first large outbreak in Romania in 1996, with a high number of cases with neuroinvasive disease. WNV has now spread globally, with the first case in the Western Hemisphere being identified in New York City in 1999; over the next 5 years, the virus spread across the continental United States, north into Canada, and southward into the Caribbean Islands and Latin America. WNV also spread to Europe, beyond the Mediterranean Basin, and a new strain of the virus was identified in Italy in 2012. WNV is now considered to be an endemic pathogen in Africa, Asia, Australia, the Middle East, Europe and in the United States, which in 2012 has experienced one of its worst epidemics. In 2012, WNV killed 286 people in the United States, with the state of Texas being hard hit by this virus, making the year the deadliest on record for the United States.
Antigen Description
West Nile Virus (WNV) is a single-stranded RNA (positive sense) virus of the family Flaviviridae, genus Flavivirus, commonly found in Africa, West Asia and the Middle East. It causes disease that is characterized by flu-like symptoms. In a small number of cases this can develop into West Nile Encephalitis (infection of the brain and spinal cord). The viral envelope consists of envelope E and membrane M proteins. The roles of the E protein include virion assembly, recognition of cell receptors, cell endosomal membrane fusion, agglutination of red blood cells, and induction of immune responses.
Keywords
West Nile Virus Envelope Protein; WNV Envelope Protein
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