Product Overview
Recombinant SARS-CoV Matrix protein containing 182-216 amino acids immunodominant regions was expressed in E. coli and purified by proprietary chromatographic technique.
Tag/Conjugate
Unconjugated
Alternative Names
SARS Matrix Protein; SARS; SARS M Protein; SARS M
Purity
> 95% pure as determined by 10% PAGE (coomassie staining).
Buffer
50mM Tris-HCl, 60mM NaCl, and 50% glycerol.
Storage
2-8°C short term, -20°C long term
Introduction
SARS Coronavirus is an enveloped virus containing three outer structural proteins, namely the membrane (M), envelope (E), and spike (S) proteins. Spike (S)-glycoprotein of the virus interacts with a cellular receptor and mediates membrane fusion to allow viral entry into susceptible target cells. Accordingly, S-protein plays an important role in virus infection cycle and is the primary target of neutralizing antibodies.
Keywords
SARS Matrix Protein; SARS; SARS M Protein; SARS M
Citations
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Du, LY; Zhao, GY; et al. Intranasal vaccination of recombinant adeno-associated virus encoding receptor-binding domain of severe acute respiratory syndrome coronavirus (SARS-CoV) spike protein induces strong mucosal immune responses and provides long-term protection against SARS-CoV infection. JOURNAL OF IMMUNOLOGY 180:948-956(2008).
Wang, ZJ; Yuan, ZH; et al. Immune responses with DNA vaccines encoded different gene fragments of severe acute respiratory syndrome coronavirus in BALB/c mice. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 327:130-135(2005).
COA
Certificate of Analysis
