RuV Capsid (DAG1979)

RuV Capsid (aa 1-123), recombinant protein from E. coli Datasheet

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Product Overview
The E.Coli derived recombinant protein contains the Rubella Virus Capsid C regions, 1-123 amino acids.
Nature
Recombinant
Tag/Conjugate
Unconjugated
Purity
> 95%, based on SDS PAGE
Format
Each vial contains 100 μg of lyophilized protein in 20mM imidazol, 8M urea and 0.3M NaCl.
Concentration
N/A
Storage
2-8°C short term, -20°C long term
Introduction
Rubella virus is the only member of the Rubrivirus genus of the Togavirus family. Unlike most Togaviruses it is NOT arthropod borne, but is acquired via the respiratory route. It causes German measles ( a mild contagious eruptive disease, capable of producing congenital defects in infants born to mothers infected during the first three months of pregnancy).
Antigen Description
The capsid protein (CP) has different functions. Its main tasks are the formation of homooligomeres to form the capsid, and the binding of the genomic RNA. Further is it responsible for the aggregation of RNA in the capsid, it interacts with the membrane proteins E1 and E2 and binds the human host-protein p32 which is important for replication of the virus in the host.As opposed to alpha viruses the capsid does not undergo autoprotolysis, rather is it cut off from the rest of the polyprotein by the signal-peptidase. Production of the capsid happens at the surface of intracellular membranes simultaneously with the budding of the virus.
Keywords
Coat protein; german measles; german measles capsid protein; p110; rubella capsid; Structural polyprotein; Rubella Virus Capsid; Togaviridae; Rubivirus

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