Recombinant RSV Active Src [GST]

Product Overview

Recombinant full-length Rous sarcoma virus Src was expressed by baculovirus in Sf 9 insect cells using an N-terminal GST tag. The gene accession number is M11753

Nature

Recombinant

Tag/Conjugate

GST

Purity

The purity was determined to be > 90% by densitometry

Concentration

0.1 μg/μL.

Preservative

None

Storage

2-8°C short term, -20°C long term

Introduction

Proto-oncogene tyrosine-protein kinase Src is an enzyme that in humans is encoded by the SRC gene. Src is a proto-oncogene encoding a tyrosine kinase originally discovered by J. Michael Bishop and Harold E. Varmus, for which they won the 1989 Nobel Prize in Physiology or Medicine. It belongs to a family of non-receptor tyrosine kinases called Src family kinases. The discovery of Src family proteins has been instrumental to the modern understanding of cancer as a disease where normally healthy cellular signalling has gone awry. This gene is similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.

Keywords

c SRC; cSrc; EC 2.7.10.2; Neuronal CSRC tyrosine specific protein kinase; Neuronal SRC; Oncogene SRC; OTTHUMP00000030931; OTTHUMP00000174476; OTTHUMP00000174477; p60 Src; p60-Src; p60Src; pp60c src; pp60c-src; pp60csrc; Proto oncogene tyrosine protein kin