HIV Glycoprotein 70 (AE/A244) [His] (DAG2146)

HIV Glycoprotein 70 (AE/A244) [His], recombinant protein from HEK 293 cells Datasheet

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Product Overview
C-terminal 6xHis tagged gp70(MLV)-V1V2(HIV-1/CN54) fusion protein containing V1V2 loops from HIV-1(Clade AE/A244). A244 is the strain used in RV144(The Thai trial).
Nature
Recombinant
Tag/Conjugate
His
Purity
≥ 95%
Format
Each vial contains 100 μg of purified protein in PBS.
Concentration
1 mg/ml
Storage
2-8°C short term, -20°C long term
Introduction
Human immunodeficiency virus (HIV) is a lentivirus (a member of the retrovirus family) that causes acquired immunodeficiency syndrome (AIDS), a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive. Infection with HIV occurs by the transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk. Within these bodily fluids, HIV is present as both free virus particles and virus within infected immune cells. The four major routes of transmission are unsafe sex, contaminated needles, breast milk, and transmission from an infected mother to her baby at birth (perinatal transmission). Screening of blood products for HIV has largely eliminated transmission through blood transfusions or infected blood products in the developed world. The murine leukemia viruses (MLVs or MuLVs) are retroviruses named for their ability to cause cancer in murine (mouse) hosts. Some MLVs may infect other vertebrates. MLVs include both exogenous and endogenous viruses. Replicating MLVs have a positive sense, single-stranded RNA (ssRNA) genome that replicates through a DNA intermediate via the process of reverse transcription.
Antigen Description
Variable regions 1 and 2 (V1/V2) of human immunodeficiency virus-1 (HIV-1) gp120 envelope glycoprotein are critical for viral evasion of antibody neutralization, and are themselves protected by extraordinary sequence diversity and N-linked glycosylation.Glycoproteins are proteins that contain oligosaccharide chains (glycans) covalently attached to polypeptide side-chains. The carbohydrate is attached to the protein in a cotranslational or posttranslational modification. This process is known as glycosylation. In proteins that have segments extending extracellularly, the extracellular segments are often glycosylated. Glycoproteins are often important integral membrane proteins, where they play a role in cell–cell interactions. Glycoproteins are also formed in the cytosol, but their functions and the pathways producing these modifications in this compartment are less well understood. The role of the murine leukemia virus (MLV) envelope glycoprotein, gp70, in the formation of the target antigen recognized by in vivo generated MLV-immune cytotoxic
Keywords
Env; Env polyprotein; Envelope glycoprotein gp70; Envelope Protein gp70; Glycoprotein 70; GP70; Human Immunodeficiency Virus 1; Human Immunodeficiency Virus Type 1 V1V2; HIV-1 V1V2; Human Immunodeficiency Virus-1 V1V2; Retroviridae; Lentivirus; Muri

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