Mouse GRO-alpha, KC, recombinant protein from E. coli
RecombinantMouse KC also known as N51 and GRO-1 is a single, non-glycosylatedpolypeptide chain containing 77 amino acids and having a molecular weight of8 kDa. Sequence: RLATGAPIANELRCQ CLQTMAGIHL KNIQSLKVLP SGPHCTQTEV IATLKNGREACLDPEAPLVQ KIVQKMLKGV PK
Purified, Lyophilized. Reconstitute using sterile deionized water to a concentration 100μg/ml. Further dilutions can be made in other aqueou buffers.
1 mg/ml(OD280nm, E0.1% = 0.03) (prior to lyophilization)
2-8°C short term, -20°C long term
This gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signal through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Jan 2012]
Has chemotactic activity for neutrophils. May play a rolein inflammation and exerts its effects on endothelial cells in an autocrinefashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) andGRO-alpha(6-73) show a 30-fold higher chemotactic activity.
CXCL1; chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha); FSP; GRO1; GROa; MGSA; NAP-3; SCYB1; MGSA-a; growth-regulated alpha protein; MGSA alpha; GRO-alpha(1-73); C-X-C motif chemokine 1; fibroblast secretory protein; neutrop