JEV PreM/M [His] (DAG2403)

JEV PreM/M (aa 6 - 167) [His], recombinant protein from E. coli Datasheet

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Product Overview
C-terminal 6xHis tagged PreM/M Protein (Japanese encephalitis virus) (a.a. 6-167)
Nature
Recombinant
Tag/Conjugate
His
Purity
> 95%, based on SDS PAGE
Format
Each vial contains 100 μg of lyophilized protein in PBS with 8M Urea.
Concentration
N/A
Storage
2-8°C short term, -20°C long term
Introduction
Dengue virus (DENV) in one of four serotypes is the cause of dengue fever. It is a mosquito-borne single positive-stranded RNA virus of the family Flaviviridae; genus Flavivirus. All four serotypes can cause the full spectrum of disease. Its genome is about 11000 bases that codes for three structural proteins, capsid protein C, membrane protein M, envelope protein E; seven nonstructural proteins, NS1, NS2a, NS2b, NS3, NS4a, NS4b, NS5; and short non-coding regions on both the 5' and 3' ends. Further classification of each serotype into genotypes often relates to the region where particular strains are commonly found or were first found.
Antigen Description
The flavivirus viron contains an envelope glycoprotein(E), a membrane protein (M) and a capsid protein (C). These three structural proteins are synthesized in the orderof C, M and E from the 5' half of a single long open reading frame of the flavivirus genome. The M protein is foundin infected cells as a glycosylated precursor, called premembrane protein (preM). The preM and E proteins appear to be released from the nascent polyprotein following cotranslational cleavage by signal peptidases. Late in viron maturation, preM is cleaved to M, presumably by a cellular protease located in the secretary pathway, and M appears to be the predominant species present in extracellular virus particles although some uncleaved preM is also present.
Keywords
membrane glycoprotein precursor; Dengue virus 1; Flavivirus; PreM/M; PreM; DENV prM; DENV prM (membrane) protein; DV1 PreM/M; Dengue Virus 1 PreM/M Protein

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