Human Thrombopoietin (DAG344)

Human Thrombopoietin, recombinant protein from E. coli Datasheet

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Purified, Lyophilized Reconstitute in 5mM Tris, pH 8.0 to aconcentration of 0.5-1.0 mg/ml. This solution can be diluted into otheraqueou buffers and stored at 2-8°C (up to one week) or –20°C for future use.
Lyophilizedfrom 5mM Tris, pH 8.0
2-8°C short term, -20°C long term
Megakaryocytopoiesis is the cellular development process that leads to platelet production. The main functional protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternative promoter usage and differential splicing result in multiple transcript variants differing in the 5 UTR and/or coding region. Multiple AUG codons upstream of the main open reading frame (ORF) have been identified, and these upstream AUGs inhibit translation of the main ORF at different extent. [provided by RefSeq, Feb 2014]
Antigen Description
Thrombopoietin (leukemia virus oncogene ligand, megakaryocytegrowth and development factor), also known as TPO, is a glycoprotein hormoneproduced mainly by the liver and the kidney that regulates the production ofplatelets by the bone marrow. It stimulate
THPO; thrombopoietin; ML; TPO; MGDF; MKCSF; MPLLG; THCYT1; MPL ligand; c-mpl ligand; prepro-thrombopoietin; megakaryocyte stimulating factor; megakaryocyte colony-stimulating factor; megakaryocyte growth and development factor; myeloproliferative leukemia


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