Human Protein Kinase C Beta I, recombinant protein from Baculovirus
RecombinantHuman Protein Kinase C (PKC) Beta I. Not enzymatically active.
Suspended inSDS/mercaptoethanol sample buffer with a bromophenol blue dye marker.
2-8°C short term, -20°C long term
Calcium-activated and phospholipid-dependent serine/threonine-protein kinase involved in various processes such as regulation of the B-cell receptor (BCR) signalosome, apoptosis and transcription regulation. Plays a key role in B-cell activation and function by regulating BCR-induced NF-kappa-B activation and B-cell suvival. Required for recruitment and activation of the IKK kinase to lipid rafts and mediates phosphorylation of CARD11/CARMA1 at Ser-559, Ser-644 and Ser-652, leading to activate the NF-kappa-B signaling. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates Ser-36 of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of Thr-6 of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 Lys-4 (H3K4me) by LSD1/KDM1A. Also involved in triglyceride homeostasis. Serves as the receptor for phorbol esters, a class of tumor promoters.
Proteinkinase C (PKC) is a family of serine- and threonine-specific protein kinasesthat can be activated by calcium and second messenger diacylglycerol. PKCfamily members phosphorylate a wide variety of protein targets and are knownto be involved in diverse cellular signaling pathways. PKC family membersalso serve as major receptors for phorbol esters, a class of tumor promoters.Each member of the PKC family has a specific expression profile and isbelieved to play a distinct role in cells. The protein encoded by this geneis one of the PKC family members. This protein kinase has been reported to beinvolved in many different cellular functions, such as B cell activation,apoptosis induction, endothelial cell proliferation, and intestinal sugarabsorption. Studies in mice also suggest that this kinase may also regulate neuronalfunctions and correlate fear-induced conflict behavior after stress.Alternatively spliced transcript variants encoding distinct isoforms havebeen reported. This gene could be associated with autism.
PRKCB; protein kinase C, beta; Pkcb; Prkcb1; Prkcb2; PKC-Beta; A130082F03Rik; protein kinase C beta type; PKC-B; protein kinase C beta-II; protein kinase C, beta 1;