Human Protein Kinase C Alpha (DAG261)

Human Protein Kinase C Alpha, recombinant protein from Baculovirus Datasheet

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Product Overview
RecombinantHuman Protein Kinase C (PKC) Alpha. Not enzymatically active.
Nature
Recombinant
Tag/Conjugate
Unconjugated
Format
Purified, Liquid
Concentration
20μg/ml
Buffer
Suspended in SDS/mercaptoethanolsample buffer with a bromophenol blue dye marker.
Preservative
None
Storage
2-8°C short term, -20°C long term
Introduction
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2008]
Antigen Description
Proteinkinase C alpha (PKCα), also known as PRKCA, refers to both a human gene andthe protein that is encoded by it. Protein kinase C (PKC) is a family ofserine- and threonine-specific protein kinases that can be activated bycalcium and the second messenger diacylglycerol. PKC family membersphosphorylate a wide variety of protein targets and are known to be involvedin diverse cellular signaling pathways. PKC family members also serve asmajor receptors for phorbol esters, a class of tumor promoters. Each memberof the PKC family has a specific expression profile and is believed to play adistinct role in cells. The protein encoded by this gene is one of the PKCfamily members. This kinase has been reported to play roles in many differentcellular processes, such as cell adhesion, cell transformation, cell cyclecheckpoint, and cell volume control. Knockout studies in mice suggest thatthis kinase may be a fundamental regulator of cardiac contractility and Ca2+handling in myocytes.
Keywords
PRKCA; protein kinase C, alpha; AAG6; PKCA; PRKACA; PKC-alpha; protein kinase C alpha type; PKC-A; aging-associated gene 6;

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