HPV type 18 [GST] (DAG1574)

HPV type 18 [GST], recombinant protein from E. coli

Product Overview
Recombinant HPV 18 Protein fused to a GST-Tag is expressed in E. coli and has a total Mw of 83kDa, purified by standard chromatography.
Nature
Recombinant
Tag/Conjugate
GST
Procedure
None
Purity
> 95% pure as determined by 12% PAGE (Coomassie staining).
Buffer
formulated with 1xPBS, 20mM arginine and 0.02% sodium azide as preservative.
Preservative
0.02% Sodium Azide
Storage
2-8°C short term, -20°C long term
Introduction
Human papillomavirus (HPV) is a DNA virus from the papillomavirus family that is capable of infecting humans. Like all papillomaviruses, HPVs establish productive infections only in keratinocytes of the skin or mucous membranes. Most HPV infections are subclinical and will cause no physical symptoms; however, in some people subclinical infections will become clinical and may cause benign papillomas (such as warts [verrucae] or squamous cell papilloma), or cancers of the cervix, vulva, vagina, penis, oropharynx and anus. HPV has been linked with an increased risk of cardiovascular disease. In addition, HPV 16 and 18 infections are a cause of a unique type of oropharyngeal (throat) cancer.
Antigen Description
L1 is a major capsid protein of type 18 human papilloma virus. Infection with specific types of HPV has been associated with an increased risk of developing cervical neoplasia. HPV types 6 and 11 have been associated with relatively benign diseases such as genital warts but types 16 and 18 are strongly associated with cervical, vaginal, and vulvar malignancies.
Keywords
HPV 18; Human papillomavirus 18

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