Human Laminin-5 (DAG282)

Human Laminin-5, recombinant protein from HEK 293 cells Datasheet

Online Inquiry Add to basket

Product Overview
HumanLaminin-5, Recombinant. Molecular weight 450kDa. Does not contain a fusionpartner.
Nature
Recombinant
Tag/Conjugate
Unconjugated
Format
Purified, Liquid
Concentration
Lotspecific
Buffer
30mMTris-HCl, pH 8.0 containing 0.0025% Brij 35, 0.05% CHAPS and 0.05% TFA
Preservative
None
Storage
2-8°C short term, -20°C long term
Introduction
This gene encodes one of the vertebrate laminin alpha chains. Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. The protein encoded by this gene is the alpha-5 subunit of of laminin-10 (laminin-511), laminin-11 (laminin-521) and laminin-15 (laminin-523).
Antigen Description
Laminin,the most abundant structural and biologically active component in basementmembranes, is a complex extracellular glycoprotein with an approximatemolecular weight of 900 kDa. It plays an important role in many aspects ofthe cell biology. Laminin is composed of one A chain (400 kDa) one B1 chain(215 kDa) and one B2 chain (205 kDa) all held together by disulfide bonds.The molecule has a cross like form with globular units near the ends of eachchain, the sites where it is bound to Collagen IV, heparan sulfate,proteoglycan as well as to the surface of epithelial cells. Laminins fromvarious species have common antigenic determinants.
Keywords
LAMA5; laminin, alpha 5; laminin subunit alpha-5; laminin alpha-5 chain; laminin-10 subunit alpha; laminin-11 subunit alpha; laminin-15 subunit alpha;

Citations


Have you cited DAG282 in a publication? Let us know and earn a reward for your research.

Customer Reviews


Write a review, share your experiences with others and get rewarded !

Online Inquiry

Name
Phone *
E-mail Address *
Service & Products Interested *
Project Description
Verification Code * Please input "diagnostics" as verification code.

Online Inquiry

Order Info: Human Laminin-5

Online Inquiry
  Interested in larger quantities ? request a quote!
  Protocol may be improved. Please feel free to contact us to obtain the latest version.!
  15% off your first purchase

Ordering Information

Payment methods we support:
Invoice / Purchase Order
Credit card

OUR PROMISE TO YOU Guaranteed product quality expert customer support

Inquiry Basket