Human Laminin-5

Product Overview

HumanLaminin-5, Recombinant. Molecular weight 450kDa. Does not contain a fusionpartner.

Nature

Recombinant

Tag/Conjugate

Unconjugated

Format

Purified, Liquid

Concentration

Lotspecific

Buffer

30mMTris-HCl, pH 8.0 containing 0.0025% Brij 35, 0.05% CHAPS and 0.05% TFA

Preservative

None

Storage

2-8°C short term, -20°C long term

Introduction

This gene encodes one of the vertebrate laminin alpha chains. Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. The protein encoded by this gene is the alpha-5 subunit of of laminin-10 (laminin-511), laminin-11 (laminin-521) and laminin-15 (laminin-523).

Antigen Description

Laminin,the most abundant structural and biologically active component in basementmembranes, is a complex extracellular glycoprotein with an approximatemolecular weight of 900 kDa. It plays an important role in many aspects ofthe cell biology. Laminin is composed of one A chain (400 kDa) one B1 chain(215 kDa) and one B2 chain (205 kDa) all held together by disulfide bonds.The molecule has a cross like form with globular units near the ends of eachchain, the sites where it is bound to Collagen IV, heparan sulfate,proteoglycan as well as to the surface of epithelial cells. Laminins fromvarious species have common antigenic determinants.

Keywords

LAMA5; laminin, alpha 5; laminin subunit alpha-5; laminin alpha-5 chain; laminin-10 subunit alpha; laminin-11 subunit alpha; laminin-15 subunit alpha;