Human La/SSB (DAG264)

Human La/SSB, recombinant protein from E. coli Datasheet

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Product Overview
SS-B(La) Antigen, Recombinant. Full length recombinant human La/SSB autoantigen.Contains 6-HIS tag.
Nature
Recombinant
Tag/Conjugate
Unconjugated
Format
Purified, Liquid
Concentration
1 mg/ml (Bradford)
Buffer
20mM Phosphate, pH7.8 containing 500mM Sodium chloride
Preservative
None
Storage
2-8°C short term, -20°C long term
Introduction
The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein.
Antigen Description
Lais involved in diverse aspects of RNA metabolism, including binding andprotecting 3-prime UUU(OH) elements of newly RNA polymerase III-transcribedRNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as anRNA chaperone, and binding viral RNAs associated with hepatitis C virus. Laprotein was originally defined by its reactivity with autoantibodies frompatients with systemic lupus erythematosus.
Keywords
SSB; Sjogren syndrome antigen B (autoantigen La); lupus La protein; La; La ribonucleoprotein domain family; member 3; LARP3; MGC118101; Sjoegren syndrome type B antigen; Autoantigen La; La; La autoantigen; La autoantigen homolog; La protein; La ribonucleo

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